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Pathophysiological changes while in the periphery and central nervous system lead to peripheral and central sensitization, therefore transitioning the inadequately managed acute pain into a chronic pain state or persistent pain problem (3). Although noxious stimuli typically trigger the perception of pain, it can even be produced by lesions in the
The soma of nociceptors are generally tiny in diameter in the two the dorsal pathway As well as in other sensory ganglia. Neurons with little soma diameter ordinarily have myelinated Aδ fibers or unmyelinated C fibers, even though Aα/β-fibers can be found on cells of more substantial Proportions. Soma diameter and axon myelination usually are no
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